Majors offered at University of Virginia's College at Wise are classified by the U.S. Department of Education under the following instructional programs:

	Associates	Bachelors	Certificate	Masters	Doctoral
Biological and Physical Sciences
Business, Management, Marketing, and Related Support Services
Business/Commerce, General
Computer and Information Sciences and Support Services
Computer Science
Computer Software Engineering
Engineering
English Language and Literature, General
English Language and Literature/letters
Health Professions and Related Programs
History
History, General
Liberal Arts and Sciences, General Studies and Humanities
Liberal Arts and Sciences/Liberal Studies
Management Information Systems, General
Mathematics and Statistics
Mathematics, General
Multi-/interdisciplinary Studies, General
Registered Nursing/Registered Nurse
Social Sciences
Social Sciences, General